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Article

Early epithelial signaling center governs tooth budding morphogenesis.

The Journal of cell biology - 12 Sept 2016

Ahtiainen Laura, Uski Isa, Thesleff Irma, Mikkola Marja L

Abstract excerpt

During organogenesis, cell fate specification and patterning are regulated by signaling centers, specialized clusters of morphogen-expressing cells. In many organs, initiation of development is marked by bud formation, but the cellular mechanisms involved are ill defined. Here, we use the mouse incisor tooth as a model to study budding morphogenesis. We show that a group of nonproliferative epithelial cells...

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Identifiers

PMID: 27621364
DOI: 10.1083/jcb.201512074
PMCID: PMC5021093

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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