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Article

Role of Hertwig's epithelial root sheath cells in tooth root development.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Dec 2003

Zeichner-David Margarita, Oishi Keiji, Su Zhengyan, Zakartchenko Vassili, Chen Li-Sha, Arzate Higinio, Bringas Pablo

Abstract excerpt

During tooth development, after the completion of crown formation, the apical mesenchyme forms the developing periodontium while the inner and outer enamel epithelia fuse below the level of the crown cervical margin to produce a bilayered epithelial sheath termed Hertwig's epithelial root sheath (HERS). The role of HERS cells in root formation is widely accepted; however, the precise function of these cells...

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Identifiers

PMID: 14648842
DOI: 10.1002/dvdy.10404

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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