Article
Interaction between the C-260T polymorphism of the CD14 gene and the plasma IL-6 concentration on the risk of myocardial infarction: the HIFMECH study.
Atherosclerosis - 1 Apr 2005
Morange P E, Saut N, Alessi M C, Frere C, Hawe E, Yudkin J S, Tremoli E, Margaglione M, Di Minno G, Hamsten A, Humphries S E, Juhan-Vague I
Abstract excerpt
Experimental and clinical observations suggest that innate immunity plays a major role in the pathogenesis and progression of atherosclerosis. A common C-260T polymorphism in the promoter of the CD14 gene, the trans-membrane receptor of lipopolysaccharides, has been inconsistently associated with coronary heart disease. Our objective was to evaluate the contribution of the CD14 polymorphism to the inflammatory...
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