Article
KIR and HLA Genotypes Implicated in Reduced Killer Lymphocytes Immunity Are Associated with Vogt-Koyanagi-Harada Disease.
PloS one - 1 Jan 2016
Levinson Ralph D, Yung Madeline, Meguro Akira, Ashouri Elham, Yu Fei, Mizuki Nobuhisa, Ohno Shigeaki, Rajalingam Raja
Abstract excerpt
Cytotoxic T lymphocytes (CTL) and natural killer (NK) cells are killer lymphocytes that provide defense against viral infections and tumor transformation. Analogous to that of CTL, interactions of killer-cell immunoglobulin-like receptors (KIR) with specific human leukocyte antigen (HLA) class I ligands calibrate NK cell education and response. Gene families encoding KIRs and HLA ligands are located on different...
Topics
- Asian People
- Chromosomes, Human
- Female
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- HLA-DR4 Antigen
- Humans
- Immunity, Cellular
- Japan
- Killer Cells, Natural
- Male
- Receptors, KIR
- Uveomeningoencephalitic Syndrome