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Article

KIR and HLA Genotypes Implicated in Reduced Killer Lymphocytes Immunity Are Associated with Vogt-Koyanagi-Harada Disease.

PloS one - 1 Jan 2016

Levinson Ralph D, Yung Madeline, Meguro Akira, Ashouri Elham, Yu Fei, Mizuki Nobuhisa, Ohno Shigeaki, Rajalingam Raja

Abstract excerpt

Cytotoxic T lymphocytes (CTL) and natural killer (NK) cells are killer lymphocytes that provide defense against viral infections and tumor transformation. Analogous to that of CTL, interactions of killer-cell immunoglobulin-like receptors (KIR) with specific human leukocyte antigen (HLA) class I ligands calibrate NK cell education and response. Gene families encoding KIRs and HLA ligands are located on different...

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Identifiers

PMID: 27490240
DOI: 10.1371/journal.pone.0160392
PMCID: PMC4973954

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Source receipt: pubmed, retrieved 7 Sept 2026.

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