Article
VEGF gene variability and type 1 diabetes: evidence for a protective role.
Immunogenetics - 1 Apr 2006
Del Bo Roberto, Scarlato Marina, Ghezzi Serena, Maestroni Anna, Sjölind Lisa, Forsblom Carol, Wessman Maija, Groop Per-Henrik, Comi Giacomo Pietro, Bresolin Nereo, Luzi Livio, Zerbini Gianpaolo
Abstract excerpt
Vascular endothelial growth factor (VEGF) is a multifunctional cytokine originally described as an angiogenic factor. A number of reports have recently demonstrated that VEGF increases pancreatic islet survival after islet transplantation by stimulating angiogenesis and improving islet revascularization. Whether VEGF can protect from the autoimmune destruction of insulin-producing beta-cells that characterizes...
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