Article
Consensus micro RNAs governing the switch of dormant tumors to the fast-growing angiogenic phenotype.
PloS one - 1 Jan 2012
Almog Nava, Ma Lili, Schwager Christian, Brinkmann Bastian G, Beheshti Afshin, Vajkoczy Peter, Folkman Judah, Hlatky Lynn, Abdollahi Amir
Abstract excerpt
Tumor dormancy refers to a critical stage in cancer development in which tumor cells remain occult for a prolonged period of time until they eventually progress and become clinically apparent. We previously showed that the switch of dormant tumors to fast-growth is angiogenesis dependent and requires a stable transcriptional reprogramming in tumor cells. Considering microRNAs (miRs) as master regulators of...
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