Article
Transcriptional switch of dormant tumors to fast-growing angiogenic phenotype.
Cancer research - 1 Feb 2009
Almog Nava, Ma Lili, Raychowdhury Raktima, Schwager Christian, Erber Ralf, Short Sarah, Hlatky Lynn, Vajkoczy Peter, Huber Peter E, Folkman Judah, Abdollahi Amir
Abstract excerpt
Tumor dormancy has important implications for early detection and treatment of cancer. Lack of experimental models and limited clinical accessibility constitute major obstacles to the molecular characterization of dormant tumors. We have developed models in which human tumors remain dormant for a prolonged period of time (>120 days) until they switch to rapid growth and become strongly angiogenic. These...
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