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Article

Heterogeneity of angiogenic activity in a human liposarcoma: a proposed mechanism for "no take" of human tumors in mice.

Journal of the National Cancer Institute - 18 Jul 2001

Achilles E G, Fernandez A, Allred E N, Kisker O, Udagawa T, Beecken W D, Flynn E, Folkman J

Abstract excerpt

BACKGROUND: Tumor cells are known to be heterogeneous with respect to their metastatic activity, proliferation rate, and activity of several enzymes. However, little is known about the heterogeneity of tumor angiogenic activity. We investigated whether heterogeneity of angiogenic activity could be responsible for the well-known observation of "no take" of human tumors transplanted into immunodeficient mice....

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Source

Identifiers

PMID: 11459868
DOI: 10.1093/jnci/93.14.1075

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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