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Article

The inverse relationship between reduced folate carrier function and pemetrexed activity in a human colon cancer cell line.

Molecular cancer therapeutics - 1 Feb 2006

Chattopadhyay Shrikanta, Zhao Rongbao, Krupenko Sergey A, Krupenko Natalia, Goldman I David

Abstract excerpt

Pemetrexed, a new generation antifolate recently approved for the treatment of mesothelioma and non-small cell lung cancer, is an excellent substrate for the reduced folate carrier (RFC). To explore the carrier's effect on pemetrexed activity, RFC was inactivated in HCT-15 colon cancer cells by mutagenesis and PT632 selective pressure. A clone (PT1) was obtained with a glycine to arginine substitution at amino...

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Identifiers

PMID: 16505119
DOI: 10.1158/1535-7163.MCT-05-0243

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The inverse relationship between reduced folate carrier function and pemetrexed activity in a human colon cancer cell line.PMID 16505119Read ↗

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Role of proton-coupled folate transporter in pemetrexed resistance of mesothelioma: clinical evidence and new pharmacological toolsSemantic proximity Read ↗

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