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Article

A P425R mutation of the proton-coupled folate transporter causing hereditary folate malabsorption produces a highly selective alteration in folate binding.

American journal of physiology. Cell physiology - 1 May 2012

Shin Daniel Sanghoon, Zhao Rongbao, Yap Enghui H, Fiser Andras, Goldman I David

Abstract excerpt

Proton-coupled folate transporter (PCFT) mediates folate intestinal absorption and transport across the choroid plexus, processes defective in subjects with hereditary folate malabsorption (HFM). PCFT is also widely expressed in human solid tumors where it contributes to the transport of pemetrexed and other antifolates. This study defines the basis for the functional changes due to a P425R mutation detected in a...

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Identifiers

PMID: 22345511
DOI: 10.1152/ajpcell.00435.2011
PMCID: PMC3361945

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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