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Folate transporter dynamics and therapy with classic and tumor-targeted antifolates

18 Mar 2021

Abstract excerpt

There are three major folate uptake systems in human tissues and tumors, including the reduced folate carrier (RFC), folate receptors (FRs) and proton-coupled folate transporter (PCFT). We studied the functional interrelationships among these systems for the novel tumor-targeted antifolates AGF94 (transported by PCFT and FRs but not RFC) and AGF102 (selective for FRs) versus the classic antifolates pemetrexed,...

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PMID: 33737637
DOI: 10.1038/s41598-021-85818-x

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