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Article

Status of c-myc, p53 and retinoblastoma genes in human papillomavirus positive and negative squamous cell carcinomas of the anus.

Oncogene - 1 Jul 1991

Crook T, Wrede D, Tidy J, Scholefield J, Crawford L, Vousden K H

Abstract excerpt

We have examined a series of squamous cell carcinomas (SCC) of the anus, anal intraepithelial neoplasia grade III (AINII) lesions and haemorrhoids for the presence of sequences from transforming human papillomavirus (HPV) types by polymerase chain reaction (PCR)/Southern blotting. In addition, the same DNAs have been analysed for abnormalities in the c-myc, p53 and retinoblastoma (Rb-1) gene loci by Southern...

Topics

Anus Neoplasms
Base Sequence
Carcinoma, Squamous Cell
Cell Transformation, Neoplastic
Cell Transformation, Viral
DNA Probes
DNA, Neoplasm
DNA, Viral
Deoxyribonuclease EcoRI
Gene Amplification

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Retinoblastoma

Genes, myc

Genes, p53

Humans

Molecular Sequence Data

Mutation

Nucleic Acid Hybridization

Papillomaviridae

Source

Identifiers

PMID: 1650445

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1650445-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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