Article
Human papillomavirus DNA and oncogene alterations in colorectal tumors.
Pathology oncology research : POR - 1 Sept 2010
Pérez Luis Orlando, Barbisan Gisela, Ottino Anabel, Pianzola Horacio, Golijow Carlos Daniel
Abstract excerpt
The aim of the present study is to determine the presence and molecular integrity of high-risk HPV types in colorectal adenocarcinomas and to assess whether viral DNA is related to common proto-oncogene alterations, such as k-ras mutations and c-myc gene amplification, in colorectal cancer. Seventy-five colorectal adenocarcinomas were screened for HPV infection using nested-PCR (MY09/11-GP5+/6+). HPV typing was...
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