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Article

Role of hybrid tRNA-binding states in ribosomal translocation.

Proceedings of the National Academy of Sciences of the United States of America - 8 Jul 2008

Walker Sarah E, Shoji Shinichiro, Pan Dongli, Cooperman Barry S, Fredrick Kurt

Abstract excerpt

During translation, tRNAs must move rapidly to their adjacent sites in the ribosome while maintaining precise pairing with mRNA. This movement (translocation) occurs in a stepwise manner with hybrid-state intermediates, but it is unclear how these hybrid states relate to kinetically defined events of translocation. Here we analyze mutations at position 2394 of 23S rRNA in a pre-steady-state kinetic analysis of...

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Identifiers

PMID: 18591673
DOI: 10.1073/pnas.0710146105
PMCID: PMC2453706

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Role of hybrid tRNA-binding states in ribosomal translocation.PMID 18591673Read ↗

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Identification of two distinct hybrid state intermediates on the ribosome.Semantic proximity Read ↗

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