Article
Inhibition of hSP-B promoter in respiratory epithelial cells by a dominant negative retinoic acid receptor.
The American journal of physiology - 1 Mar 1999
Ghaffari M, Whitsett J A, Yan C
Abstract excerpt
Retinoic acid (RA) receptors (RARs) belong to the nuclear hormone receptor superfamily and play important roles in lung differentiation, growth, and gene regulation. Surfactant protein (SP) B is a small hydrophobic protein synthesized and secreted by respiratory epithelial cells in the lung. Expression of the SP-B gene is modulated at the transcriptional and posttranscriptional levels. In the present work,...
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