Article
Developmental and genetic regulation of human surfactant protein B in vivo.
Neonatology - 1 Jan 2009
Hamvas Aaron, Heins Hillary B, Guttentag Susan H, Wegner Daniel J, Trusgnich Michelle A, Bennet Kate W, Yang Ping, Carlson Christopher S, An Ping, Cole F Sessions
Abstract excerpt
BACKGROUND: Genetic and developmental disruption of surfactant protein B (SP-B) expression causes neonatal respiratory distress syndrome (RDS). OBJECTIVES: To assess developmental and genetic regulation of SP-B expression in vivo. METHODS: To evaluate in vivo developmental regulation of SP-B, we used immunoblotting to compare frequency of detection of mature and pro-SP-B peptides in developmentally distinct...
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