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Article

Human SP-A 3'-UTR variants mediate differential gene expression in basal levels and in response to dexamethasone.

American journal of physiology. Lung cellular and molecular physiology - 1 May 2003

Wang Guirong, Guo Xiaoxuan, Floros Joanna

Abstract excerpt

Human surfactant protein A (SP-A) is encoded by two genes (SP-A1, SP-A2), and each is identified with several alleles. SP-A is involved in normal lung function, innate immunity, inflammatory processes, and is regulated by glucocorticoids. We investigated the role of 3'-untranslated region (UTR) of 10 SP-A variants on gene expression using transient transfection of 3'-UTR constructs in the human lung...

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Identifiers

PMID: 12676764
DOI: 10.1152/ajplung.00375.2002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Human SP-A 3'-UTR variants mediate differential gene expression in basal levels and in response to dexamethasone.PMID 12676764Read ↗

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