Article
In vivo identification of genes that modify ether-a-go-go-related gene activity in Caenorhabditis elegans may also affect human cardiac arrhythmia.
Proceedings of the National Academy of Sciences of the United States of America - 10 Aug 2004
Petersen Christina I, McFarland Toni R, Stepanovic Svetlana Z, Yang Ping, Reiner David J, Hayashi Kenshi, George Alfred L, Roden Dan M, Thomas James H, Balser Jeffrey R
Abstract excerpt
Human ether-a-go-go-related gene (HERG) encodes the pore-forming subunit of I(Kr), a cardiac K(+) channel. Although many commonly used drugs block I(Kr), in certain individuals, this action evokes a paradoxical life-threatening cardiac rhythm disturbance, known as the acquired long QT syndrome (aLQTS). Although aLQTS has become the leading cause of drug withdrawal by the U.S. Food and Drug Administration, DNA...
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