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Article

Endosome sorting and autophagy are essential for differentiation and virulence of Leishmania major.

The Journal of biological chemistry - 21 Apr 2006

Besteiro Sébastien, Williams Roderick A M, Morrison Lesley S, Coombs Graham H, Mottram Jeremy C

Abstract excerpt

Cellular remodeling during differentiation is essential for life-cycle progression of many unicellular eukaryotic pathogens such as Leishmania, but the mechanisms involved are largely uncharacterized. The role of endosomal sorting in differentiation was analyzed in Leishmania major by overexpression of a dominant-negative ATPase, VPS4. VPS4(E235Q) accumulated in vesicles from the endocytic pathway, and the mutant...

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PMID: 16497676
DOI: 10.1074/jbc.M512307200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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