Article
Expression of constitutively active Rab5 uncouples maturation of the Salmonella-containing vacuole from intracellular replication.
Cellular microbiology - 1 Jul 2001
Baldeón M E, Ceresa B P, Casanova J E
Abstract excerpt
The enteric bacterial pathogen Salmonella typhimurium enters and proliferates within both phagocytic and non-phagocytic host cells. Upon entry, the bacteria reside in membrane-bound vacuoles (SCVs) that mature with time, as evidenced by the sequential loss of early endosomal markers, followed by the selective recruitment of a number of lysosomal membrane glycoproteins (LAMPs). This remodelling process renders the...
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