Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Leishmania donovani resides in modified early endosomes by upregulating Rab5a expression via the downregulation of miR-494

26 Jun 2017

Abstract excerpt

Several intracellular pathogens arrest the phagosome maturation in the host cells to avoid transport to lysosomes. In contrast, the Leishmania containing parasitophorous vacuole (PV) is shown to recruit lysosomal markers and thus Leishmania is postulated to be residing in the phagolysosomes in macrophages. Here, we report that Leishmania donovani specifically upregulates the expression of Rab5a by degrading c-Jun...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium signaling and nucleotide metabolism
Share to Cellular transport and secretion
Share to Trypanosoma species research and implications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28650977
DOI: 10.1371/journal.ppat.1006459

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Leishmania donovani resides in modified early endosomes by upregulating Rab5a expression via the downregulation of miR-494PMID 28650977Read ↗

Identification and Characterization of miRNAs in Response to Leishmania donovani Infection: Delineation of Their Roles in Macrophage DysfunctionSemantic proximity Read ↗

<i>Leishmania</i> and the Macrophage: A Multifaceted InteractionSemantic proximity Read ↗

Leishmania infection upregulates and engages host macrophage Argonaute 1, and system-wide proteomics reveals Argonaute 1-dependent host responseSemantic proximity Read ↗

Impaired recruitment of the small GTPase rab7 correlates with the inhibition of phagosome maturation by Leishmania donovani promastigotes.Semantic proximity Read ↗

<i>Leishmania</i> infection triggers hepcidin-mediated proteasomal degradation of Nramp1 resulting in increased phagolysosomal iron availabilitySemantic proximity Read ↗

MicroRNA expression profiling of <i>Leishmania donovani</i> -infected host cells uncovers the regulatory role of MIR30A-3p in host autophagySemantic proximity Read ↗

Leishmania (Leishmania) Amazonensis Promastigotes With Distinct Virulence Profile and Their Extracellular Vesicles Differently Modulate the Macrophage FunctionsSemantic proximity Read ↗

Immunomodulatory Impact of Leishmania-Induced Macrophage Exosomes: A Comparative Proteomic and Functional AnalysisSemantic proximity Read ↗

<i>Leishmania amazonensis</i> amastigotes invade non-phagocytic cells via highly localized parasite-induced actin remodelingSemantic proximity Read ↗

Absence of metalloprotease GP63 alters the protein content of Leishmania exosomes.Semantic proximity Read ↗

Deciphering the Role Played by Autophagy in Leishmania InfectionSemantic proximity Read ↗

Expression of constitutively active Rab5 uncouples maturation of the Salmonella-containing vacuole from intracellular replication.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.