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Article

Non-cell-autonomous action of STAT3 in maintenance of neural precursor cells in the mouse neocortex

26 May 2006

Abstract excerpt

The transcription factor STAT3 promotes astrocytic differentiation of neural precursor cells (NPCs) during postnatal development of the mouse neocortex, but little has been known of the possible role of STAT3 in the embryonic neocortex. We now show that STAT3 is expressed in NPCs of the mouse embryonic neocortex and that the JAK-STAT3 signaling pathway plays an essential role in the maintenance of NPCs by...

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PMID: 16728475
DOI: 10.1242/dev.02419

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