Article
Identification of limited regions of genetic aberrations in patients affected with Wilms' tumor using a tiling-path chromosome 22 array.
International journal of cancer - 1 Aug 2006
Benetkiewicz Magdalena, Díaz de Ståhl Teresita, Gördör Anita, Pfeifer Susan, Wittmann Stefanie, Gessler Manfred, Dumanski Jan P
Abstract excerpt
Wilms' tumor (WT) is one of the most common solid tumors of childhood. The genetics of this disorder is complex and few studies have suggested allelic loss of chromosome 22 as a frequent aberration. To assess tumor- and possible germline-specific regions affected with gene copy number variations on this chromosome, we applied a high-resolution genomic clone-based chromosome 22 array to a series of 28 WT samples...
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