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Article

Mapping neuroinvasiveness of the herpes simplex virus type 1 encephalitis-inducing strain 2762 by the use of monoclonal antibodies.

Molecular and cellular probes - 1 Feb 1992

Bergström T, Sjögren-Jansson E, Jeansson S, Lycke E

Abstract excerpt

Monoclonal antibodies (MAbs) directed against herpes simplex virus (HSV)-coded glycoproteins gB, gC, gD and gE were employed in a an in vitro model of neuroinvasiveness using sensory neurons from rat dorsal root ganglion (DRG) cells. The neurons were cultured in at two-chamber system allowing infection via the neuritic extensions exclusively. The effects of 30 MAbs on viral replication of the encephalitis-derived...

Topics

Animals
Antibodies, Monoclonal
Cells, Cultured
Encephalitis
Ganglia, Spinal
Glycoproteins
Humans
Male
Mice
Middle Aged
Mutation
Rats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats, Inbred Strains

Simplexvirus

Viral Envelope Proteins

Virulence

Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 1312221
DOI: 10.1016/0890-8508(92)90070-e
PMCID: PMC7135814

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1312221-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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