Two novel single amino acid syncytial mutations in the carboxy terminus of glycoprotein B of herpes simplex virus type 1 confer a unique pathogenic phenotype.

doi:10.1006/viro.1993.1013

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Article

Two novel single amino acid syncytial mutations in the carboxy terminus of glycoprotein B of herpes simplex virus type 1 confer a unique pathogenic phenotype.

Virology - 1 Jan 1993

Engel J P, Boyer E P, Goodman J L

Abstract excerpt

We previously reported on a variant of the herpes simplex type 1 (HSV-1) strain 17 syn+, named 17 hep syn, capable of forming giant polykaryocytes (syncytia) in tissue culture and which induced a striking alteration in the pathogenesis of infection in vivo. Following footpad inoculation of mice,...

Topics

Amino Acid Sequence
Animals
Base Sequence
Cell Fusion
Chromosome Mapping
Male
Mice
Molecular Sequence Data
Mutation
Oligodeoxyribonucleotides
Point Mutation
Simplexvirus
Vero Cells
Viral Envelope Proteins

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