Article
The impact of data quality on the identification of complex disease genes: experience from the Family Blood Pressure Program.
European journal of human genetics : EJHG - 1 Apr 2006
Chang Yen-Pei Christy, Kim James Dae-Ok, Schwander Karen, Rao Dabeeru C, Miller Mike B, Weder Alan B, Cooper Richard S, Schork Nicholas J, Province Michael A, Morrison Alanna C, Kardia Sharon L R, Quertermous Thomas, Chakravarti Aravinda
Abstract excerpt
The application of genome-wide linkage scans to uncover susceptibility loci for complex diseases offers great promise for the risk assessment, treatment, and understanding of these diseases. However, for most published studies, linkage signals are typically modest and vary considerably from one study to another. The multicenter Family Blood Pressure Program has analyzed genome-wide linkage scans of over 12 000...
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