Article
Comprehensive linkage and linkage heterogeneity analysis of 4344 sibling pairs affected with hypertension from the Family Blood Pressure Program.
Genetic epidemiology - 1 Apr 2007
Greenwood Tiffany A, Libiger Ondrej, Kardia Sharon, Hanis Craig, Morrison Alanna C, Gu C Charles, Rice Treva, Miller Michael, Turner Stephen T, Myers Richard H, Grove John, Hsiao Chin-Fu, Weder Alan B, Schork Nicholas J
Abstract excerpt
Linkage analyses of complex, multifactorial traits and diseases, such as essential hypertension, have been difficult to interpret and reconcile. Many published studies provide evidence suggesting that different genes and genomic regions influence hypertension, but knowing which of these studies reflect true positive results is challenging. The reasons for this include the diversity of analytical methods used...
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