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Structural, functional and molecular dynamics analysis of <i>cathepsin B</i> gene SNPs associated with tropical calcific pancreatitis, a rare disease of tropics

2018-04-26

Abstract excerpt

Tropical Calcific Pancreatitis (TCP) is a neglected juvenile form of chronic non-alcoholic pancreatitis. Cathepsin B (CTSB), a lysososmal protease involved in cellular degradation process, is recently been studied as a potential candidate gene in the pathogenesis of TCP. According to cathepsin B hypothesis, mutated CTSB can lead to premature intracellular activation of trypsinogen, which is a key regulatory mecha...

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Literature Corpus work
61188414-6df1-5c7b-b51e-16035972972e
DOI
10.1101/308932
Open publication

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