Article
Use of spontaneous Epstein-Barr virus-lymphoblastoid cell lines genetically modified to express tumor antigen as cancer vaccines: mutated p21 ras oncogene in pancreatic carcinoma as a model.
Human gene therapy - 1 May 2002
Kubuschok Boris, Schmits Rudolf, Hartmann Frank, Cochlovius Christiane, Breit Rainer, König Jochem, Pistorius Georg, Schilling Martin, Renner Christoph, Pfreundschuh Michael
Abstract excerpt
Spontaneous Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines (SP-LCLs) can be easily obtained from latently EBV-infected cancer patients and used as a source of antigen-presenting cells (APCs) for immunotherapy. Using point-mutated (codon 12) p21(ras) (muRas) as a model tumor antigen, we evaluated the practicability of using genetically modified SP-LCLs as cancer vaccines for patients with...
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