Article
Mammary tumorigenesis following transgenic expression of a dominant negative CHK2 mutant.
Cancer research - 15 Feb 2006
Kwak Eunice L, Kim Sang, Zhang Jianmin, Cardiff Robert D, Schmidt Emmett V, Haber Daniel A
Abstract excerpt
A truncating allele of the cell cycle checkpoint kinase CHK2 is present in 1% of the population, conferring a moderate increase in breast cancer risk, and inactivation of chk2 enhances mammary tumorigenesis in mice with targeted inactivation of brca1. We used the mouse mammary tumor virus (MMTV) promoter to target expression of a kinase-dead CHK2 allele (D347A). Mammary tumors, of predominantly micropapillary...
Topics
- Alleles
- Animals
- Checkpoint Kinase 2
- Female
- Gene Expression Regulation, Enzymologic
- Gene Expression Regulation, Neoplastic
- Gene Silencing
- Humans
- Mammary Neoplasms, Experimental
- Mammary Tumor Virus, Mouse