Article
A low molecular weight agonist signals by binding to the transmembrane domain of thyroid-stimulating hormone receptor (TSHR) and luteinizing hormone/chorionic gonadotropin receptor (LHCGR).
The Journal of biological chemistry - 14 Apr 2006
Jäschke Holger, Neumann Susanne, Moore Susanna, Thomas Craig J, Colson Anny-Odile, Costanzi Stefano, Kleinau Gunnar, Jiang Jian-Kang, Paschke Ralf, Raaka Bruce M, Krause Gerd, Gershengorn Marvin C
Abstract excerpt
Many cognate low molecular weight (LMW) agonists bind to seven transmembrane-spanning receptors within their transmembrane helices (TMHs). The thienopyrimidine org41841 was identified previously as an agonist for the luteinizing hormone/chorionic gonadotropin receptor (LHCGR) and suggested to bind within its TMHs because it did not compete for LH binding to the LHCGR ectodomain. Because of its high homology with...
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