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Article

Genetic mouse models of autism spectrum disorder present subtle heterogenous cardiac abnormalities.

Autism research : official journal of the International Society for Autism Research - 1 Jul 2022

Assimopoulos Stephania, Hammill Christopher, Fernandes Darren J, Spencer Noakes Tara Leigh, Zhou Yu-Qing, Nutter Lauryl M J, Ellegood Jacob, Anagnostou Evdokia, Sled John G, Lerch Jason P

Abstract excerpt

Autism spectrum disorder (ASD) and congenital heart disease (CHD) are linked on a functional and genetic level. Most work has investigated CHD-related neurodevelopmental abnormalities. Cardiac abnormalities in ASD have been less studied. We investigated the prevalence of cardiac comorbidities relative to ASD genetic contributors. Using high frequency ultrasound imaging, we screened 9 ASD-related genetic mouse...

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Identifiers

PMID: 35445787
DOI: 10.1002/aur.2728
PMCID: PMC9325472

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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