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Article

Netrin-1 acts as a repulsive guidance cue for sensory axonal projections toward the spinal cord.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 8 Oct 2008

Masuda Tomoyuki, Watanabe Keisuke, Sakuma Chie, Ikenaka Kazuhiro, Ono Katsuhiko, Yaginuma Hiroyuki

Abstract excerpt

During early development, the ventral spinal cord expresses chemorepulsive signals that act on dorsal root ganglion (DRG) axons to help orient them toward the dorsolateral part of the spinal cord. However, the molecular nature of this chemorepulsion is mostly unknown. We report here that netrin-1 acts as an early ventral spinal cord-derived chemorepellent for DRG axons. In the developing mouse spinal cord,...

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Identifiers

PMID: 18842897
DOI: 10.1523/JNEUROSCI.1926-08.2008
PMCID: PMC6671023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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