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Article

Cytokine signalling in embryonic stem cells

1 Nov 2005

Abstract excerpt

Cytokines play a central role in maintaining self-renewal in mouse embryonic stem (ES) cells through a member of the interleukin-6 type cytokine family termed leukemia inhibitory factor (LIF). LIF activates the JAK-STAT3 pathway through the class I cytokine receptor gp130, which forms a trimeric complex with LIF and the class I cytokine receptor LIF receptor beta. STAT3 has been shown to play a crucial role in...

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Identifiers

PMID: 16480448
DOI: 10.1111/j.1600-0463.2005.apm_391.x

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