Article
Constitutive and specific activation of STAT3 by BCR-ABL in embryonic stem cells.
Oncogene - 26 Jun 2003
Coppo Paul, Dusanter-Fourt Isabelle, Millot Gael, Nogueira Maria Manuela, Dugray Aymeric, Bonnet Marie Laure, Mitjavila-Garcia Maria Theresa, Le Pesteur Dominique, Guilhot Francosie, Vainchenker William, Sainteny Francoise, Turhan Ali G
Abstract excerpt
BCR-ABL oncogene, the molecular hallmark of chronic myelogenous leukemia (CML) arises in a primitive hematopoietic stem cell with both differentiation and self-renewal ability. To study the phenotypic effects of BCR-ABL in a clonal in vitro self-renewal and differentiation model, we have introduced BCR-ABL in the ES cell line CCE. The major effect of BCR-ABL expression was the persistence of primitive morphology...
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