Maintenance of the pluripotential phenotype of embryonic stem cells through direct activation of gp130 signalling pathways.

doi:10.1016/0925-4773(94)90030-2

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Article

Maintenance of the pluripotential phenotype of embryonic stem cells through direct activation of gp130 signalling pathways.

Mechanisms of development - 1 Feb 1994

Yoshida K, Chambers I, Nichols J, Smith A, Saito M, Yasukawa K, Shoyab M, Taga T, Kishimoto T

Abstract excerpt

Propagation of the undifferentiated pluripotential phenotype of embryonic stem (ES) cells is dependent on the cytokine differentiation inhibiting activity/leukemia inhibitory factor (DIA/LIF). The DIA/LIF receptor complex is a heterodimer of DIA/LIF receptor (DIA/LIF-R) and gp130. The latter is a...

Topics

Amino Acid Sequence
Animals
Antigens, CD
Blastocyst
Cell Differentiation
Cells, Cultured
Chimera
Cytokine Receptor gp130
Female
Gene Expression Regulation
Growth Inhibitors
Interleukin-6
Leukemia Inhibitory Factor
Leukemia Inhibitory Factor Receptor alpha Subunit

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Open in PubMed

Identifiers

PMID: 8199053
DOI: 10.1016/0925-4773(94)90030-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8199053-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Lymphokines

Male

Membrane Glycoproteins

Mice