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Article

Notch and transforming growth factor-beta (TGFbeta) signaling pathways cooperatively regulate vascular smooth muscle cell differentiation.

The Journal of biological chemistry - 4 Jun 2010

Tang Yuefeng, Urs Sumithra, Boucher Joshua, Bernaiche Tyler, Venkatesh Deepak, Spicer Douglas B, Vary Calvin P H, Liaw Lucy

Abstract excerpt

Notch and transforming growth factor-beta (TGFbeta) play pivotal roles during vascular development and the pathogenesis of vascular disease. The interaction of these two pathways is not fully understood. The present study utilized primary human smooth muscle cells (SMC) to examine molecular cross-talk between TGFbeta1 and Notch signaling on contractile gene expression. Activation of Notch signaling using Notch...

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Identifiers

PMID: 20368328
DOI: 10.1074/jbc.M109.076414
PMCID: PMC2878520

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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