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Article

Multiplex analysis of expression of three IFNβ-induced genes in antibody-positive MS patients

13 Feb 2006

Abstract excerpt

Some interferon beta (IFNbeta)-treated patients with multiple sclerosis develop antibody-mediated decreased bioactivity with resultant loss of therapeutic effect. The authors developed real-time multiplex reverse transcriptase PCR to measure expression of three IFNbeta-inducible genes to directly assess IFNbeta bioactivity in patients with neutralizing antibodies (NAbs). The three genes responded in tandem....

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PMID: 16476953
DOI: 10.1212/01.wnl.0000196467.71646.72

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