Article
Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase.
The Journal of biological chemistry - 14 Apr 2006
Taurin Sebastien, Sandbo Nathan, Qin Yimin, Browning Darren, Dulin Nickolai O
Abstract excerpt
Beta-catenin is a signaling molecule that promotes cell proliferation by the induction of gene transcription through the activation of T-cell factor (TCF)/lymphoid enhancer factor (LEF) transcription factors. The canonical mechanism of the regulation of beta-catenin involves its phosphorylation by casein kinase 1 at the Ser-45 site and by glycogen synthase kinase 3 (GSK3) at the Thr-41, Ser-37, and Ser-33 sites....
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