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Article

TGF-beta inhibits p70 S6 kinase via protein phosphatase 2A to induce G(1) arrest.

Genes & development - 15 Dec 2000

Petritsch C, Beug H, Balmain A, Oft M

Abstract excerpt

On TGF-beta binding, the TGF-beta receptor directly phosphorylates and activates the transcription factors Smad2/3, leading to G(1) arrest. Here, we present evidence for a second, parallel, TGF-beta-dependent pathway for cell cycle arrest, achieved via inhibition of p70(s6k). TGF-beta induces ass...

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Identifiers

PMID: 11124802
DOI: 10.1101/gad.854200
PMCID: PMC317138

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11124802-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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