Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization.

Nature - 11 Apr 2002

Li Muyang, Chen Delin, Shiloh Ariel, Luo Jianyuan, Nikolaev Anatoly Y, Qin Jun, Gu Wei

Abstract excerpt

The p53 tumour suppressor is a short-lived protein that is maintained at low levels in normal cells by Mdm2-mediated ubiquitination and subsequent proteolysis. Stabilization of p53 is crucial for its tumour suppressor function. However, the precise mechanism by which ubiquitinated p53 levels are regulated in vivo is not completely understood. By mass spectrometry of affinity-purified p53-associated factors, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endopeptidases
Share to Genes, Dominant
Share to Mass Spectrometry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proto-Oncogene Proteins

Share to Proto-Oncogene Proteins c-mdm2

Share to Tumor Suppressor Proteins

Share to Ubiquitin

Share to Ubiquitin Thiolesterase

Source

Identifiers

PMID: 11923872
DOI: 10.1038/nature737

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization.PMID 11923872Read ↗

Emerging insights into HAUSP (USP7) in physiology, cancer and other diseasesSemantic proximity Read ↗

<scp>HAUSP</scp>, a novel deubiquitinase for Rb – <scp>MDM</scp>2 the critical regulatorSemantic proximity Read ↗

The deubiquitinase inhibitor WP1130 drives nuclear aggregation and reactivation of mutant p53 for selective cancer cell targeting.Semantic proximity Read ↗

Regulation of p53 stability as a therapeutic strategy for cancer.Semantic proximity Read ↗

The HAUSP gene plays an important role in non-small cell lung carcinogenesis through p53-dependent pathways.Semantic proximity Read ↗

Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde.Semantic proximity Read ↗

A portrayal of E3 ubiquitin ligases and deubiquitylases in cancerSemantic proximity Read ↗

Targeting the Ubiquitin-Mediated Proteasome Degradation of p53 for Cancer TherapySemantic proximity Read ↗

Trim24 targets endogenous p53 for degradation.Semantic proximity Read ↗

The Ubiquitin System and Kaposi’s Sarcoma-Associated HerpesvirusSemantic proximity Read ↗

The Regulation of p53 by Ubiquitination and Implications for Therapeutic Targeting in Colorectal Cancer.Semantic proximity Read ↗

The deubiquitinating enzyme USP24 is a regulator of the UV damage response.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.