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Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells

1 Aug 2009

Abstract excerpt

Deregulation of the ubiquitin/proteasome system has been implicated in the pathogenesis of many human diseases, including cancer. Ubiquitin-specific proteases (USP) are cysteine proteases involved in the deubiquitination of protein substrates. Functional connections between USP7 and essential viral proteins and oncogenic pathways, such as the p53/Mdm2 and phosphatidylinositol 3-kinase/protein kinase B networks,...

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PMID: 19671755
DOI: 10.1158/1535-7163.mct-09-0097

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