Pituitary cell translation and secretory capacities are enhanced cell autonomously by the transcription factor Creb3l2

Abstract excerpt

Translation is a basic cellular process and its capacity is adapted to cell function. In particular, secretory cells achieve high protein synthesis levels without triggering the protein stress response. It is unknown how and when translation capacity is increased during differentiation. Here, we show that the transcription factor Creb3l2 is a scaling factor for translation capacity in pituitary secretory cells...

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