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Critical role of tripartite fusion and LBD truncation in certain RARA- and all RARG-related atypical APL

24 Jul 2024

Abstract excerpt

ABSTRACT: Atypical acute promyelocytic leukemia (aAPL) presents a complex landscape of retinoic acid receptor (RAR) fusion genes beyond the well-known PML::RARA fusion. Among these, 31 individually rare RARA and RARG fusion genes have been documented, often reported in the canonical X::RAR bipartite fusion form. Intriguingly, some artificially mimicked bipartite X::RAR fusions respond well to all-trans retinoic...

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PMID: 39046762
DOI: 10.1182/blood.2024023883

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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