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Article

Exogenous 8-oxo-dG is not utilized for nucleotide synthesis but enhances the accumulation of 8-oxo-Gua in DNA through error-prone DNA synthesis.

Mutation research - 11 Apr 2006

Kim Ja-Eun, Hyun Jin-Won, Hayakawa Hiroshi, Choi Seongwon, Choi Jinhee, Chung Myung-Hee

Abstract excerpt

7,8-Dihydro-8-oxoguanine (8-oxo-Gua) and its nucleoside in cytosol are derived from the repair of oxidative DNA and the cleanup of oxidatively damaged DNA precursors, respectively. While the harmful effects of 8-oxo-Gua present in DNA have been studied extensively, few have reported its effects on cytosolic function. Our previous study showed that the addition of 8-oxo-dG to culture media caused an accumulation...

Read the complete abstract on PubMed

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Source

Identifiers

PMID: 16472828
DOI: 10.1016/j.mrfmmm.2005.12.004

Genes

OGG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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