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Article

Docosahexaenoic acid selectively inhibits plasma membrane targeting of lipidated proteins.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Apr 2006

Seo Jeongmin, Barhoumi Rola, Johnson Arthur E, Lupton Joanne R, Chapkin Robert S

Abstract excerpt

Membrane localization of lipidated cytosolic signaling proteins is mediated by interactions between specific lipid anchors and membranes, but little is known about the regulatory role of membrane composition in lipidated protein membrane targeting. Here, using green fluorescent protein (GFP) chimeras and quantitative fluorescence microscopy in living mouse colonocytes, we show that docosahexaenoic acid (DHA), a...

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PMID: 16469846
DOI: 10.1096/fj.05-4683fje

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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