Article
CD36 facilitates fatty acid uptake by dynamic palmitoylation-regulated endocytosis.
Nature communications - 21 Sept 2020
Hao Jian-Wei, Wang Juan, Guo Huiling, Zhao Yin-Yue, Sun Hui-Hui, Li Yi-Fan, Lai Xiao-Ying, Zhao Ning, Wang Xu, Xie Changchuan, Hong Lixin, Huang Xi, Wang Hong-Rui, Li Cheng-Bin, Liang Bin, Chen Shuai, Zhao Tong-Jin
Abstract excerpt
Fatty acids (FAs) are essential nutrients, but how they are transported into cells remains unclear. Here, we show that FAs trigger caveolae-dependent CD36 internalization, which in turn delivers FAs into adipocytes. During the process, binding of FAs to CD36 activates its downstream kinase LYN, which phosphorylates DHHC5, the palmitoyl acyltransferase of CD36, at Tyr91 and inactivates it. CD36 then gets...
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