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Article

The endogenous estrogen status regulates microglia reactivity in animal models of neuroinflammation.

Endocrinology - 1 May 2006

Vegeto Elisabetta, Belcredito Silvia, Ghisletti Serena, Meda Clara, Etteri Sabrina, Maggi Adriana

Abstract excerpt

It has been previously demonstrated that 17beta-estradiol (E(2)) inhibits the response of microglia, the resident brain macrophages, to acute injuries in specific brain regions. We here show that the effect of E(2) in acute brain inflammation is widespread and that the hormone reduces the expression of inflammatory mediators, such as monocyte chemoattractant protein-1, macrophage inflammatory protein-2, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16469811
DOI: 10.1210/en.2005-1330

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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