Article
Testicular zinc finger protein recruits histone deacetylase 2 and suppresses the transactivation function and intranuclear foci formation of agonist-bound androgen receptor competitively with TIF2.
Molecular and cellular endocrinology - 9 Mar 2006
Tao Rong-Hua, Kawate Hisaya, Wu Yin, Ohnaka Keizo, Ishizuka Masamichi, Inoue Atsuto, Hagiwara Hiromi, Takayanagi Ryoichi
Abstract excerpt
We previously reported that testicular zinc finger protein (TZF) is a corepressor for androgen receptor (AR). The present study demonstrated that a central portion (amino acids 512-663) of TZF, TZF(512-663), is responsible for both binding to AR and repressing the transactivation. TZF recruited endogenous histone deacetylase 2 (HDAC2) and formed a complex with agonist-bound AR. Imaging analyses showed that TZF...
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