Article
The nuclear receptor homologue Ftz-F1 and the homeodomain protein Ftz are mutually dependent cofactors.
Nature - 6 Feb 1997
Guichet A, Copeland J W, Erdélyi M, Hlousek D, Závorszky P, Ho J, Brown S, Percival-Smith A, Krause H M, Ephrussi A
Abstract excerpt
Nuclear hormone receptors and homeodomain proteins are two classes of transcription factor that regulate major developmental processes. Both depend on interactions with other proteins for specificity and activity. The Drosophila gene fushi tarazu (ftz), which encodes a homeodomain protein (Ftz), is required zygotically for the formation of alternate segments in the developing embryo. Here we show that the orphan...
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